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Autoren:
Verlag:
Spektrum-Akademischer Vlg Weitere Titel dieses Verlages anzeigen
I | ||
Inhalt | ||
Einleitung | 3 | |
KLASSISCHE GENETIK | ||
01 | Die Evolutionstheorie | 4 |
02 | Die Vererbungsgesetze | 8 |
03 | Gene und Chromosomen | 12 |
04 | Die Genetik der Evolution | 16 |
05 | Mutationen | 20 |
06 | Sex | 24 |
MOLEKULARBIOLOGIE | ||
07 | Gene, Proteine und DNA | 28 |
08 | Die Doppelhelix | 32 |
09 Entschlüsselung des genetischen | ||
Codes | 36 | |
10 | Genmanipulation | 40 |
DAS GENOM | ||
11 | Das Lesen des Genoms | 44 |
12 | Das menschliche Genom | 48 |
13 | Lektionen des Genoms | 52 |
ERBE ODER UMWELT | ||
14 | Genetischer Determinismus | 56 |
15 | Egoistische Gene | 60 |
16 | Das unbeschriebene Blatt | 64 |
17 | Erbe und Umwelt | 68 |
GENE UND GESUNDHEIT | ||
18 | Erbkrankheiten | 72 |
19 | Die Jagd nach den Genen | 76 |
20 | Krebs | 80 |
21 | Superkeime | 84 |
SEK, GESCHICHTE UND VERHALTEN | ||
22 | Verhaltensgenetik | 88 |
23 | Intelligenz | 92 |
24 | Rasse | 96 |
25 | Genetische Urgeschichte | 100 |
26 Genetische Stammbaumforschung | ||
104 | ||
27 | Geschlechtsspezifische Gene | 108 |
28 | Das Ende der Männer? | 112 |
29 | Der Kampf der Geschlechter | 116 |
30 | Homosexualität | 120 |
GENTECHNIK | ||
31 | Genetische Fingerabdrücke | 124 |
32 | Transgene Pflanzen | 128 |
33 | Transgene Tiere | 132 |
34 | Evo Devo | 136 |
35 | Stammzellen | 140 |
36 | Klonen | 144 |
37 | Menschen klonen | 148 |
38 | Gentherapie | 152 |
39 | Gentests | 156 |
40 | Maßgeschneiderte Medikamente | 160 |
41 | Designerbabys | 164 |
42 | Schöne neue Welten | 168 |
43 | Gene und Versicherungen | 172 |
44 | Patentierung von Genen | 176 |
DIE NEUE GENETIK | ||
45 | Junk-DNA | 180 |
46 | Kopienzahlvarianten | 184 |
47 | Epigenetik | 188 |
48 | Die RNA-Revolution | 192 |
49 | Künstliches Leben | 196 |
50 | Die Illusion der Normalität | 00 |
Glossar | 04 | |
Index | 06 | |
Impressum | 08 | |
Index
10OO-Genome-Projekt 79
A
Afrika 96-98, 100-102
Alkaptonuria 28
Allele 9,10,17-20,71
Alzheimer-Krankheit 110,
156, 158
Aminosäuren 36-39
Artbildung 19
Aschkenasim 97-99, 157
Asilomar-Konferenz 42
ASPM 95
Assoziationsstudien, genom- weite 77, 78
Auslese, natürliche 4, 7, 16-20, 22
Australopithecus afarensis 100
Autismus 73,186,187,201
Autosomen 13-15
Avery, Oswald 30
B
Bacillus thuringiensis s. Bt Bakteriophagen s. Phagen Baron-Cohen, Simon 110, 111
Basen(-paare) 31, 34, 35, 117
Beadle, George 29, 52
Berg, Paul 41-43
Birkenspanner 18
Bluterkrankheit 72,73,112
Blutgruppen 10
Boyer, Herbert 42, 43
BRAF 81,82
BRCA 72,82,156-158,
174, 176, 178, 179
Brustkrebs 72, 156, 163,
176, 178, 179
Bt 128-130
C
Caenorhabditis elegans 52, 135
Case Control Consortium 78, 79
Caspi, Avshalom 70, 71
CCC s. Case Control Consor- tium Celera 49-51
Centromere 54, 181
Chargaff, Erwin 34
Chorea Huntington 9,11, 72-74, 76, 77, 157, 175
Chromatin 13,190
Chromosomen 12-15,25- 27
Clinton, Bill 51,179
CMLs. Leukämie Codons 39
Cohen, Stanley 42
Collins, Francis 160, 163, 164
Crick, Francis 28, 32-34,
36-39, 193
Crossing-over 24-27, 181
D
Darwin, Charles 4-8, 57, 96, 100
Über die Entstehung der Arten 7, 8, 57
Die Abstammung des Menschen 7, 96, 100
Dawkins, Richard 7, 60-63, 67
Das egoistische Gen 60, 61, 63
Determinismus, genetischer
56-59
Diabetes 75, 203
diploid 25
DNA 30-39
Junk- s. dort rekombinante 41-43
Dolly 144, 149
dominant 9-11
Doppelhelix 32-37
Down-Syndrom 13, 158
Drift, genetische 18-20,22
Drosophila melanogaster 14, 15, 20, 29, 50, 52, 136-138
Duchenne-Muskeldystrophie 73, 112
Dunedin-Kohortenstudie 70, 71
E
egoistische Gene 60-63
Einzelnucleotidpolymorphis-
men s. SNPs Eizellen 13,24,25,108, 113, 118, 144, 146, 147, 195
ENCODE 180, 182
Entwicklungsbiologie s. Evo
Devo Enzyme 28-30, 35
Epigenetik 188-191
Erbe und Umwelt 68-71
Erblichkeit 89, 90, 93
Escherichia coli 38,41 -43
ES-Zellen 140-147
Ethik 90,91,150,166-171, 199
Eugenik 21, 58, 59
Evo Devo 136-139
Evolution 4-7,16-19,60- 63, 84, 87, 98, 100-103, 121, 122
Exons 38,53,192,193
expressed sequence tags 47
Expression s. Genexpression
F
Fehlschluss, naturalistischer 62
Fettleibigkeit 203
Fingerabdruck, genetischer
124-127
Flynn-Effekt 94,95
Fortpflanzung 24-27
FOXP2 54,101,102
Franklin, Rosalind 33, 34
Fukuyama, Francis 168, 169
G
Galton, Francis 56, 58
Gameten 24, 25
Garrod, Archibald 28-29
GenBank 50
Gen-Chips 77,78,185
Gendoping 155
Genealogie s. Stammbaum-
forschung
Genetic Information Non-di-
scrimination Act s. G INA
Genexpression 53, 119,
139, 182, 190, 192, 193
Genmanipulation 22, 40-43
Genographic Project 104, 106
Genom 44-55,79,159,
180-185, 187, 196-199
Genotyp 12
Gentechnik 128-135
Gentherapie 152-155,202, 203
Geschlechtsselektion 109
GINA 173
Gould, Stephen Jay 66, 67
H
Hamer, Dean 120, 121
haploid 25
Haplotypen 27, 78, 99
HapMap 78, 99
Harris, John 150,167,170, 171
Hautfarbe 98, 99
heterozygot 9, 73, 74
HIV 84-86, 186
Homo erectus 101
Homo sapiens 100-102, 136
Homosexualität 120-123
homozygot 9, 73, 74
Hox-Gene 137-139
Humanepigenomprojekt 191
Humangenomprojekt 47-
51, 178-180, 186
Huxley, Aldous 168
Huxley, Thomas Henry 4, 5
Hwang Woo-Suk 146
ICSI 113
IGF2R 92-94
Immundefekt, schwerer kom-
binierter s. SCID
Imprinting 117-119, 149
Insulin 43, 54
Intelligent Design 5
Intelligenz 92-98
Introns 38,53,181,193
/n-wYro-Fertilisation (IVF) 13,
164-167
IPS-Zellen 143, 147
IQ s. Intelligenz
IVF s. /'n-w'fro-Fertilisation
J
Jeffreys, Alec 124,125
Junk-DNA 53-55,180-183
K
Keimbahn 153, 169
Kern s. Zellkerne Klonen 144-151
Kohanim 104
Kopienzahlvarianten 184- 187
Kopplung 10,14,15,26,77
Körpergröße 89, 94, 95
Kreationismus 5, 6
Krebs 74,75,80-83,142, 190
künstliches Leben s. Leben,
künstliches
L
Lamarck, Jean-Baptiste 5, 6
LCN-Proben 127
Leben, künstliches 196-199
Leukämie 142,154,161, 163
Lewontin, Richard 67, 98
Locke, John 64
Lovell-Badge, Robin 109, 115
low copy number s. LCN-Pro- ben
Lyssenko, Trofim Denisso- witsch 5, 21
M
Marx, Karl 64, 66
Mead, Margaret 65
Meiose 25, 27
Meme 61
Mendel, Gregor 8-12,15
Mendel'sche Regeln 8-11, 16
Messenger-RNA 37-39, 47,
192-194
Methylierung 117, 144,
189-191
Miescher, Friedrich 30
Mitochondrien 47, 151
Mitose 25
Moderne Synthese 16, 17,
19, 20, 60
Moffitt, Terrie 70, 71
Monod,Jacques 36
Morbus Tay-Sachs 9, 99, 157
Morgan, Thomas Hunt 12,
14, 15, 17, 20, 26
Moskitos, transgene 133
mRNAs. Messenger-RNA
MRS A 86
Mukoviszidose 11, 72-74,
84, 153, 155, 157
Muller, Hermann 20-23, 27, 128
Mullers Ratsche 27,113
Mullis, Kary 12,126
Muskeldystrophie s.
Duchenne-M.
Mutationen 16-23, 27, 29, 72-74, 81-83
N
Neandertaler 101
Neurospora crassa 29
Nirenberg, Marshall 36
Nucleobasen s. Basen Nucleotide 45
Nuffield Council on Bioethics
88, 91, 179
Nutrigenomik 162
O
OMIM-Datenbank 9
Onkogene 81,190
Out-of-Africa-Theorie 101 —
102
P
Paley, William 5
Patentierung 176-179
Pauling, Linus 23, 33, 34
PCR s. Polymeraseketten-
reaktion Pflanzen, transgene 128- 131
Phagen 23,30,40,41,46
Phänotyp 9, 10, 12
Pharmakogenomik 160- 163
Pharming 134
Phenylketonurie 69, 157, 162
PID 164-167
Pinker, Steven 66
Plasmide 42, 43
pleiotrop 75
Plomin, Robert 92-94
Polymerasekettenreaktion
(PCR) 125, 126
Populationsgenetik 17
Prader-Willi-Syndrom 116
Präimplantationsdiagnostik s.
PID
Proteine 28-31, 37-39, 52-
55, 193-195
Pseudogene 182
Psychologie, evolutionäre 63
R
Rasse 96-99
Rekombination 24-27, 105
Replikation 35
Restriktionsenzyme 40-42
Reverse Transkriptase 41, 86, 181
rezessiv 9-11,14,74
Ribosomen 38,39,193
RNA 31,37-39,182,192- 195
RNA-Interferenz 192,194
Röntgenstrahlung 21-23, 33, 34
S
Samenzellen s. Spermien Sanger, Fred 44-46
Schimpansen 14,53,54, 103, 185
SCID 112,152-154
SCNT 144-147, 149
Sequenzierung 44-51
Serotoninwiederaufnahme-
hemmer s. SSRI
Sex 24-27
Sichelzellenanämie 73-75, 99
Smith, Hamilton 41
SNPs 55,77,78,184,185
Spermien 13,14,24-26,
108, 113, 118, 195
Spermieninjektion, intrazyto-
plasmatische s. ICSI
Spleißen 53
Spleißosom 193
SRY 108-110, 113, 114, 174
SSRI 161,162
Stammbaumforschung 47,
104-107
Stammzellen 140-143, 166, 191
embryonale s. ES-Zellen
induzierte pluripotente s.
IPS-Zellen Staphylococcus aureus 86
Sulston, John 48, 51, 52,
56, 173, 176, 178
Sykes, Bryan 106,112,114
Synthetische Theorie s.
Moderne Synthese
T
Tabula-rasa-Theorie 64-67
Tatum, Edward 29, 52
Taufliege s. Drosophila Telomere 54,81,150,181
Thomson, Jamie 140,143
Tiere, transgene 132-135
Transhumanismus 170, 171
Transkription 37,138,189
Translation 37
Triplettcode 36-39
Tumorsuppressorgene 81, 190
V
Venter, Craig 47, 49-51, 56,
159, 178, 196-199
Verhaltensgenetik 88-91
Versicherungen 172-175
Vries, Hugo de 12
W
Wallace, Alfred Rüssel 7
Watson, James 32-34, 49,
96, 97, 158, 159, 178
Wilberforce, Samuel 5
Wilkins, Maurice 33, 34
Wilmut, lan 144
Wilson, Edward Osborne 66, 67
X
X-Chromosom 108, 109,
112, 113
X-gekoppelte Krankheiten 15, 112, 113, 164, 165
Y
Yamanaka, Shinya 143
Y-Chromosom 104-108, 110-115, 118, 123
Z
Zellkerne 12, 13, 144, 146,
147, 151
Zellkerntransfer, somatischer
s. SCNT
Zwillinge 55, 69, 70, 90, 120, 150