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Autoren:
Verlag:
Herbig Verlag Weitere Titel dieses Verlages anzeigen
Vorwort | ||
Genetisch kommt von Goethe | 7 | |
Der Physiker im Klostergarten | ||
Gregor Mendel und die Gesetze der Vererbung | 18 | |
Der erste Blick auf die Gene | ||
William Bateson, Carl Correns, Archibald Garrod, | ||
Wilhelm Johannsen | 41 | |
Die Ankunft einer Fliege | ||
Thomas Hunt Morgan und seine Schule führen | ||
die Fliege Drosophila ein | 66 | |
Die Moleküle des Lebens | ||
Die Biochemiker und der Weg | ||
zur Ein-Gen-ein-Enzym-Hypothese | 97 | |
Das Atom der Biologie | ||
Max Delbrück & Co. begründen die | ||
Molekularbiologie | 115 | |
Ein Gefühl für den Organismus | ||
Barbara McClintock - | ||
eine Frau in der Männerwelt | 136 | |
14 | ||
Am Faden des Lebens | ||
J. D. Watson, F. Crick und andere erkennen | ||
die Struktur des Erbmaterials........... | ||
Revolution in der Molekularbiologie | ||
Der genetische Code, die Synthese der Proteine, | ||
das Dogma der Molekularbiologie und | ||
die Regulation der Gene | 174 | |
Eine neue Technik bringt eine neue Genetik | ||
Werner Arber, Herbert Boyer, Paul Berg und | ||
die Faszination des Klonens | 206 | |
Die Auskunft einer Fliege | ||
Seymour Benzer und andere, die Verhalten | ||
und Genetik zusammendenken wollen | 241 | |
Hello Dolly - Vom kurzen Leben eines berühmten | ||
Schafes | ||
Über einige Grenzen der genetischen Eingriffe | 270 | |
Tausendundein Genom und mehr | ||
Walter Gilbert, Craig Venter, Francis Collins & | ||
Co. knöpfen sich die Genome vor | 285 | |
Nachwort | ||
Der genetische Stand der Dinge | 322 | |
Anhang | ||
Zeittafel | 331 | |
Ausgewählte Literatur | 334 | |
Glossar | 337 | |
Register | 344 | |
Adaptor-Hypothese 194 f.
Allele 22, 43 f.
Alpha-Helix 150
Aminosäuren 108, 112, 177 f., 180, 186, 189 f., 199 f., 224, 233, 255
Antigen 228, 230 f., 233
Antikörper 228 f., 230 ff.
Arber, Werner 207 ff., 234
Asilomar-Konferenz 219
Astbury, William 158 f.
Atome 27, 34 f., 38 f., 101 ff., 116 ff., 122 ff., 159, 185, 242, 296, 315, 328
Atomkern 118, 328
Atomverband 15, 101, 121, 153
Avery, Oswald 113, 133
Bakteriophagen 124 ff., 143,
161, 184, 207, 242
Baltimore, David 220
Bandenmuster 88
Basenpaare 165, 167 ff., 178 ff., 199, 214, 222, 243, 256, 292 f., 306, 308, 328
Bateson, William 14, 30, 43,
46 ff., 50, 57, 59, 62, 66, 252 f.
Beadle, George 106, 109
Bell, Florence 158
Benzer, Seymour 184 f., 241 ff.,
244 ff.
Berg, Paul 220, 227
Bermuda-Prinzipien 304
Biokatalysatoren 105
Biosynthese 179
Bohr, Niels 117 ff., 122
Boten 179, 188, 191,246 f.
Boten-RNA (mRNA) 191, 323
Botenmolekül 179, 221, 226
Botstein, David 236, 290
Boyer, Herbert 215
Bragg, William 150 f.
Brenner, Sydney 191, 248 f.
Bresch, Carsten 192
Bridges, Calvin 80 f., 87 f.
Brosius, Jürgen 184
Buchner, Eduard 98 ff.
California Institute of Technology (Caltech) 92, 121 ff., 169 f., 243
Castle, William E. 68 f.
Cavendish Laboratory 149 ff.,
150, 153
Chargaff, Erwin 165 f.
Chase, Martha 134 f., 163
Chromatin 56
Chromosomen des Menschen
54 f., 309
Chromosomentheorie 73
Chromosomfaden 143
Cistron 184
Cluster 260
Cochran, William 166
Code, genetischer 156, 178, 180, 182 f., 189, 199 ff., 205, 225
Coen, Enrico 267
Cohen, Daniel 299
Cohen, Stanley 215
Cold Spring Harbor Laboratory
(CSHL) 70
Collins, Francis 303 f., 306 f., 311
copy DNA (cDNA) 221, 223
Correns, Carl 41 ff., 45, 66, 76
Creighton, Harriet 140
Crick, Francis H. C. 146 f., 149 ff., 161, 164 ff., 169, 172, 176, 188 ff., 205, 220, 241, 245, 326
Crossing over 81, 140
Darwin, Charles 28, 47, 49, 94,
130 f.
Davis, Ronald W. 236, 290
de Vries, Hugo 41, 58
Degradation 177
Delbrück, Max 15, 91, 116 ff., 125 ff., 144, 152 f., 169 f., 242, 245
Desoxyribonukleinsäure (DNS)
111, 147
Diauxy-Phänomen 194
Diversität 93
DNA, kodierende 225
DNA, repetitive 301, 309
DNA-Bausteine 178, 180, 185,
199, 255
DNA-Fäden 87, 212 f., 263
DNA-Fragmente 210, 213, 294
DNA-Moleküle 174 f., 208 f.,
212 f., 222, 235, 294, 325
DNA-Schäden 289
DNA-Sequenzen 13, 184, 196,
198 f., 212, 225, 256, 271,
288,295, 300, 309, 313 f.
DNA-Struktur 169, 173, 199, 205
Dobzhansky, Theodosius 92 ff.
Domäne 229 ff., 258
Dominant 23 f., 43 ff., 76
Donohue, Jerry 166
Dopingmittel 216
Doppelhelix 146 ff., 155, 167 ff., 174, 176, 178, 172, 174, 176, 178, 186, 188, 209 ff., 221 f., 299, 306
Dounce, Alexander 186
Dulbecco, Renato 220, 234, 286,
289, 292
Dunn, Leslie 15
Ein-Exon-eine-Domäne-Hypo-
these 100
Ein-Gen-ein-Enzym-Hypothese
100, 108 f., 183
Ein-Gen-ein-Polypeptid-Hypo-
these 191, 226
Ellis, Emory 122 f., 125
Embryo 33, 232, 251, 262
Embryologie 68, 156
Embryonalentwicklung 251, 257,
265
Enhancer 225
Enzyme 99 f., 102 f., 105 f., 109, 112, 174 f., 178, 198,212, 325
Epigenetik 8, 316 ff.
Epigenome 316
Erbanlagen 32, 43, 46 f., 51, 54, 58, 63, 82, 94, 123, 248, 285
Erbgesetze 19, 48
Erbelemente 14, 22 ff., 33, 35,
38, 43, 49, 57 f., 75
Erbfaktoren 12, 38, 47, 75, 78, 142
Erbkrankheiten 18, 29, 62, 304
Erblichkeitslehre 58 f., 60
Erbmaterial 88, 93 f., 124, 126, 142, 144, 155, 162, 172, 210, 221 f., 252, 293,316,318
European Molecular Biology Laboratory (EMBL) 187
Evolution 20, 47 f., 50, 94 ff.,
226, 249 ff., 259, 265, 268,
272, 288, 309 f.
Exon 225 f., 229 ff.
Farbenblindheit 32, 61, 78
Fermentation 98 f.
Filialgeneration 22 f.
Fingerabdruck, genetischer
237 f.
Flemming, Walther 56 f.
Fluktuationstest 132
Franklin, Rosalind 164 f.
Garrod, Archibald 61 ff.
Gedächtnis 206, 247
Gedächtnis der Gene 318, 321
Gehring, Walter 249, 251, 261
Gendiagnose 8
Gene, homöotische 46 f., 252 ff.,
258 ff.
Genetik, neue 28, 119, 227, 236,
287, 291
Genforschung 10, 285, 303
Genkarte (genetische Karte) 83,
85, 236 f., 243, 290 f., 295
Genkopplung 42
Genlocus 141
Genmanipulation 213, 227
Genmutation 91, 115 f., 130, 152
Genom 143 ff., 173, 214, 251, 265, 285 ff., 292, 294, 297 ff., 304 ff., 309 ff., 316 f., 322 f., 330
Genomforschung 285, 298 ff.,
303,312
Genomprojekt 63, 239, 309, 312
Genotyp 61, 325
Genpool 94, 310
Genprodukte 216, 263
Gensequenz 12, 240, 263, 271,
300, 313, 317, 322 f.
Genstruktur 115 f., 224
Genstücke 222, 231 f.
Gentechnik 12, 205, 209, 213 ff., 217 ff., 228 f., 235 f., 256, 271, 273, 286, 289, 291, 294
Gentechnologie 276
Gentransfer 309
Gilbert, Walter 227, 294 ff.
Gosling, Raymond 164
Gould, Stephen J. 184
Hefezellen 98 f., Hershey, Alfred 132 ff., 163
Hershey-Chase-Experiment
134 f.
Homöobox 249 f., 252, 255 f.,
258 f., 261, 269
Homöodomäne 255, 259
Homöose 46
Hood, Leroy 234 f.
Hoppe-Seyler, Felix 52
Hormone 104, 178, 216, 246, 325
Humangenetik 9
Humangenom 239, 301
Individualität 9, 11 f., 63 f., 217,
235, 237
Information, genetische 7, 13,
140, 155, 173, 183, 186,
188 f., 191 f., 209,218, 225,
229, 255, 300, 314, 316 f.
Informationsträger 189
Insulin 176 ff., 180 f., 216, 227
Intron 225 f., 231
In-vitro-System 186 f., 200
J. Craig Venter Institute 300
Jacob, François 163, 188, 191,
194, 196, 202 ff., 261
Jeffreys, Alec 237
Johannsen, Wilhelm 12, 15, 58 ff., 78, 99
Keimbahn 90, 140, 273
Kendrew, John 153
Kieckhefer Foundation 157
Kitcher, Philip 15, 285
Klibansky, Raymond 262
Klon 214 f., 282, 294
Klonen 214 f., 265, 270, 272 f.,
275 ff., 282 f.
Klonschaf 270, 273 f.
Konsensus-Sequenz 310 f.
Kontrollelemente 142 ff.
Kossei, Albrecht 102 f., 110 f.
Kreativität 145, 264 ff., 268 ff.
Krebs 13, 286 ff., 291, 297, 300,
320, 323
Krebszellen 7, 55, 287
Kreuzungen 18 f., 41 ff., 48, 59, 83 f., 88, 92,115, 122
Lamarck, Jean-Baptiste de 130
Luria, Salvatore E. 129 ff., 144, 150
Lwoff, André 194
Mach, Ernst 38
Makromoleküle 103 ff., 109,
112,153,174 f., 177
Master-Proteine 266 f., 269
Matthaei, Heinrich 200 f.
McClintock, Barbara 136 ff.
Medical Research Council
(MRC) 153
Medikamente 216, 297, 300
Mendel, Gregor 10, 12 ff., 18 ff., 23, 25 ff., 37, 39 f., 42 ff., 48 f., 71 ff., 76 f., 99, 142, 245
Mendelismus 38, 75
Mendelsche Regeln 22 ff., 42, 44
messenger RNA (mRNA) 16, 179 f., 188, 191,197, 221, 222, 226, 233, 323
Methylierung 318 f.
Miescher, Friedrich 51 ff., 55, 102
Mikrobiologie 126
Mitose 57
Molekularbiologie 10, 25, 29, 100, 106, 116, 121, 124, 126, 129, 151, 153, 155 f., 159 f., 172 f., 175 f., 181 f., 187, 189, 192 ff., 201 f., 205 f., 216, 219 f., 241, 296, 326, 328
Molekulargenetik 123, 205
Moleküle 11,36, 102 f., 144,
150, 154, 156, 159, 174 f.,
177 f., 181,206,213, 237,
246, 253, 270, 287 f., 317,
319, 329 f.
Monod, Jacques 188, 191, 194,
196, 201 ff.
Morgan, Thomas H. 10, 25, 70 ff., 75 ff., 87 f., 91 ff., 97, 121, 139, 290
Mosaikgen 225 f., 255
Mosaikstruktur 225, 230 f., 308
Muller, Hermann 15, 80, 88 ff.,
103, 120
Müller-Hill, Benno 296
Mullis, Kary 238 f.
Mutation 119 ff., 130, 184, 189,
253,288
Muton 184
National Center for Human Ge- nome Research (NCHGR) 299
Neurogenetik 243, 245
Neuronen 247
Neurotransmitter 246
Nirenberg, Marshall 200 f.
Nukleinsäuren 53, 55, 102 f., 110 ff., 126, 133, 135, 143, 158, 161, 165, 180 f., 184
Nukleotide 112, 158, 165, 178 f.
Nukleus (Nucleus), vgl. Zellkern Nuon 184
Onkogene 218, 287 f.
Operator 196 ff.
Operon 196 ff.
Pardee, Arthur 188
Parentalgeneration 22
Pauling, Linus 150, 158, 170
Permease 198
Perutz, Max 150, 153
Phänotyp 60 f., 325
Poisson, Simeon Denis 127 f.
Poisson-Verteilung 127
Polymerase 198, 238
Polymerasekettenreaktion (PCR)
215, 238 f.
Polymorphismus 236, 290 f.
Polypeptid 190, 200
Portmann, Adolf 284
Primärstruktur 188 ff., 263
Programm, genetisches 261 ff.,
270, 274
Promotor 196 ff.
Proteinbausteine 178, 180, 255, 263
Proteine, Synthese von 155, 175,
179, 186, 188, 193, 323
Protoplasma 55
Recon 184
Regulation, genetische 195 ff., 201
Regulatorgene 196, 199
Rekombination 83, 184, 190,
213, 232, 243
Replikation 125
Repressor 196 f.
Reproduktion 31, 279
Restriktionsenzyme 212 ff., 289
Retroviren 221
Rezessiv 23 f., 43 ff., 62, 76, 79
RFLP (Riflip) 290 f., 299
Ribosom 179
Riesenchromosomen 87 f.
RNA-Interferenz 324
RNA-Moleküle 180, 226, 323 ff.
Roberts, Richard 223
Röntgenstrahlen 89 ff., 103, 109,
120, 150, 153, 159, 161
Rückkopplung 198 f.
Salk-Institut 156 f.
Sanger, Frederick 176 ff., 180 f., 227
Schrödinger, Erwin 152 f., 170,
185, 242
Seele 157, 162, 276 f., 282 f., 321
Selektion 47, 93 f.
Sequenzhypothese 189
Sequenzierung 227, 289, 293 f.,
296, 298, 300
Sharp, Phillip 220 ff.
Spaltungsregel 23, 43
Spezifität 178, 182, 186, 189 f.,
230, 233
Spleißen 226, 233 f.
Staudinger, Hermann 102 f.
Stent, Gunther 205
Stoffwechsel 105 ff., 153, 176,
195 f., 198, 208, 246, 296
Stoffwechselkrankheit 62
Stoffwechselstörungen 61, 63
Strukturgene 196 f., 199, 224
Sturtevant, Alfred 80 f., 83 ff., 290
Sutton, Walter 73 f.
Tatum, Edward Lawrie 106,
108 f.
Telomere 55, 320
Temin, Howard 220
The Institute for Genomic
Research (TIGR) 300
Timofeef-Ressovsky, Nikolai 91, 120
Tonegawa, Susumu 234 f.
Transfer-RNA (tRNA) 180, 323
Transformationsprinzip 114
Transkriptase 221
Transkription 179, 198, 221,
224, 226
Translation 180, 226
Triplett 180,199 f.
Tumorgene 218 f.
Tumor-Suppressor-Gen 287 f.
Umwelt 7 f., 13, 59 f., 130, 228,
265, 279 f., 318
Umweltfaktoren 75
Venter, Craig 298, 300 ff., 315, 318
Wachstum, sekundäres 129 f.
Waddington, Conrad 316 f.
Waldeyer, Heinrich Wilhelm 56
Watson, James D. 15 f., 146 ff., 154, 158 ff., 169 ff., 176, 192, 205, 299, 303
Weismann, August 89 f.
Weissenbach, Jean 299
Wilkins, Adam S. 268
Wilkins, Maurice 163 f.
Winnacker, Ernst-Ludwig 16
Zamecnik, Paul 186
Zellkern 51, 53, 56, 61, 147,
174, 312
Zellteilung 55 ff., 289
Zimmer, Karl Günter 120
Zwischenträger 155, 186, 188 f.,
191 f.
Zytogenetik 139